ChemicalBook CAS DataBase List 121-88-0

121-88-0

Name	2-Amino-5-nitrophenol
CAS	121-88-0
EINECS(EC#)	204-503-8
Molecular Formula	C6H6N2O3
MDL Number	MFCD00007692
Molecular Weight	154.12
MOL File	121-88-0.mol

Chemical Properties

Appearance	Brown to rust Crystalline powder
Melting point	198-202 °C (dec.) (lit.)
Boiling point	322.46°C (rough estimate)
density	1.3617 (estimate)
refractive index	1.6890 (rough estimate)
solubility	DMSO (Slightly), Methanol (Slightly)
form	Crystalline Powder
pka	8.08±0.19(Predicted)
color	Rust brown to brown
Water Solubility	insoluble
Detection Methods	HPLC
BRN	972974
Henry's Law Constant	1.3×10⁷ mol/(m³Pa) at 25℃, HSDB (2015)
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	2-Amino-5-nitrophenol (121-88-0)
InChI	InChI=1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2
InChIKey	DOPJTDJKZNWLRB-UHFFFAOYSA-N
SMILES	C1(O)=CC([N+]([O-])=O)=CC=C1N
CAS DataBase Reference	121-88-0(CAS DataBase Reference)
IARC	3 (Vol. 57) 1993
EPA Substance Registry System	121-88-0(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . R68:Possible risk of irreversible effects. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37:Wear suitable protective clothing and gloves . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S36:Wear suitable protective clothing . less more
RIDADR	2811
WGK Germany	2
RTECS	SJ6302500
TSCA	Yes
REACH Registrations	Active
HS Code	29222990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Hazardous Substances Data	121-88-0(Hazardous Substances Data)
Toxicity	LD50 oral in rat: > 4gm/kg less more

Raw materials And Preparation Products

Hazard Information

General Description

Brown amorphous granules or powder. Melting point 198-202°C.

Reactivity Profile

2-AMINO-5-NITROPHENOL(121-88-0) is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.

Air & Water Reactions

Is slowly oxidized by air at room temperature. Insoluble in water.

Fire Hazard

Flash point data for this chemical are not available. 2-AMINO-5-NITROPHENOL is probably combustible.

Chemical Properties

Brown to rust Crystalline powder

Uses

2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes.

Uses

2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.

Uses

Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2

Definition

ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols.

Carcinogenicity

The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.

121-88-0

Chemical Properties

Safety Data

Raw materials And Preparation Products

Raw materials

Preparation Products

Hazard Information

General Description

Reactivity Profile

Air & Water Reactions

Fire Hazard

Chemical Properties

Uses

Uses

Uses

Definition

Carcinogenicity

Purification Methods

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information