120210-48-2

Obtained from acetic acid as fluffy yellow crystals, melting point 230°C (decomposition).
Tenidap Sodium: C14H8C1N2NaO3S. [119784-94-0]. Crystallized from methanol-isopropanol, melting point 237-238°C.

Anti-inflammatory (osteoarthritis and rheumatoid arthritis).

ChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).

Store at -20°C

Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1).