1189423-58-2

5-Fluorouracil-¹³C,¹⁵N₂ is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.

Store at -20°C

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[2] TETSUYA TAMATANI. Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells.[J]. International journal of oncology, 2012, 41 3: 1148-1156. DOI: 10.3892/ijo.2012.1544