115913-32-1

Dimethyl Bicyclo[1.1.1]pentane-1,3-dicarboxylate is a useful reagent for preparation of terminally functionalized [n]staffanes.

The crude product of compound 6 obtained in the previous step was directly dissolved in methanol (200 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction solution was concentrated to obtain the crude product of compound 7. Crystallization and purification was carried out by petroleum ether to finally obtain the pure compound 7 (12.2 g) in 90% yield.

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[4] Patent: CN105294442, 2016, A. Location in patent: Paragraph 0006; 0014