1118-02-1

Clear colorless liquid

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)3 catalysis.

Trimethylsilyl Isocyanate was used in:
postsynthetic modification of isoreticular metal-organic framework-3;
synthesis of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones;
conversion of isocyanates to carbodiimides with cyclopentadienyl Fe(CO)2 or -Mn(CO)3 catalysis;
carbamoylation of aromatic hydrocarbons and alcohols

Calcium caseinate and trimethylsilyl isocyanate could be linked in chemical synthesis, where trimethylsilyl isocyanate might be used to modify the surface of calcium caseinate for creating novel biomaterials, such as controlled-release drug delivery systems or protein-based coatings.

Purify it by repeated fractionation as for the isothiocyanate. [Eaborn J Chem Soc 3077 1950, Beilstein 4 III 1861, 4 IV 4011.]