General Description
A clear colorless liquid with an ammonia-like odor. Insoluble in water and less dense than water. Hence floats on water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
Reactivity Profile
DIISOBUTYLAMINE(110-96-3) can react vigorously with oxidizing materials . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air & Water Reactions
Highly flammable. Sensitive to heat and air. Insoluble in water.
Health Hazard
Inhalation of high concentrations of vapor will cause irritation of the respiratory tract and the lungs. Contact with liquid may result in severe skin and eye irritation. Exposure to concentrated vapors may result in corneal edema. Poisonous if swallowed.
Chemical Properties
CLEAR LIQUID
Chemical Properties
The chemical reactivity of diisobutylamine is similar to other aliphatic amines and
is governed by the unshared electron pair on the nitrogen atom. It is a strong base
tending to form salts with acids. As with other secondary amines, diisobutylamine
can be nitrosated, especially under acidic conditions, by nitrite ion or by nitrogen
oxides from the air to form the carcinogenic and mutagenic N-nitrosodiisobutylamine
(Olah et al 1975).
Uses
Diisobutylamine was used to study the effect of achiral amine on hydrogenation of ethyl pyruvate over cinchonidine-Pt/Al2O3 catalyst system.
Uses
Diisobutylamine was used to study the effect of achiral amine on hydrogenation of ethyl pyruvate over cinchonidine-Pt/Al2O3 catalyst system.
Production Methods
Diisobutylamine can be produced by the reaction of ammonia and butanol over a
dehydration catalyst at high temperature and pressure (Hawley 1977). Alternatively,
ammonia, butanol, and hydrogen can be passed over a dehydrogenation
catalyst. In 1976, 18,000 tons of diisobutylamine were produced (Schweizer et al
1978). Diisobutylamine is also naturally present in foods and soil.
As with other secondary amines, diisobutylamine can be nitrosated to form the
highly toxic (Olah 1975) N-nitrosodiisobutylamine (Guttenplan 1987; Vlasenko et
al 1981; Spiegeholder et al 1978). Thus, nitrosation of commercial preparations of
diisobutylamine occurs on standing, presumably by reaction with nitrogen oxides
in the air (Spiegelhalder et al 1978) and N-nitrosodiisobutylamine has been found
in various fishery products (Kawabata et al 1974) and other foods (Osborne 1972;
Telling 1972).
Industrial uses
Diisobutylamine is used as a chemical intermediate in the manufacture of several
agricultural and pharmaceutical products.
Metabolism
There is little information available on the metabolism of diisobutylamine.
