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Name 1-Oxa-4-azacyclohexane
CAS 110-89-4
EINECS(EC#) 203-813-0
Molecular Formula C5H11N
MDL Number MFCD00005979
Molecular Weight 85.15
MOL File 110-89-4.mol

Chemical Properties

Appearance Piperidine is a clear, colorless liquid. Pepper, ammonia or amine odor.
Melting point  -11 °C
Boiling point  106 °C(lit.)
density  0.930 g/mL at 20 °C
vapor density  3 (vs air)
vapor pressure  23 mm Hg ( 20 °C)
FEMA  2908
refractive index  n20/D 1.452(lit.)
Fp  16 °C(lit.)
storage temp.  Store in dark!
solubility  miscible in water and alcohol; soluble in ether, acetone, benzene and chloroform maximum allowable concentration: not established; more toxic, irritating and volatile than pyridine (Reinhardt and Brittelli 1981).
pka 11.123(at 25℃)
Odor at 1.00 % in propylene glycol. heavy sweet floral animal
PH 12.6 (100g/l, H2O, 20°C)
Stability: Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids, organic acids, water. Vapours may flow along surfaces to a distant source of ignition.
explosive limit 1.5-10.3%(V)
Odor Type animal
Water Solubility  Miscible
Sensitive  Air Sensitive
JECFA Number 1607
Merck  14,7468
BRN  102438
Dielectric constant 5.9(20℃)
LogP 0.61
CAS DataBase Reference 110-89-4(CAS DataBase Reference)
NIST Chemistry Reference Piperidine(110-89-4)
EPA Substance Registry System 110-89-4(EPA Substance)

Safety Data

Hazard Codes  T,F
Risk Statements 
R61:May cause harm to the unborn child.
R20/21:Harmful by inhalation and in contact with skin .
R34:Causes burns.
R23/24:Toxic by inhalation and in contact with skin .
R11:Highly Flammable.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing .
RIDADR  UN 3286 3/PG 2
WGK Germany  3
RTECS  TM3500000
Autoignition Temperature 320 °C
HazardClass  8
PackingGroup  I
HS Code  29333210
Safety Profile
Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by subcutaneous route. Mildly toxic by inhalation. An experimental teratogen. Experimental reproductive effects by inhalation. A skin irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Can react vigorously with oxidzing materials. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with 1- perchloryl-piperidme, dqanofurazan, N- nitrosoacetadde. When heated to decomposition it emits highly toxic fumes of NOx. Used in agriculture and pharmaceuticals, and as an intermediate for rubber accelerators. Used in production of drugs of abuse.
Hazardous Substances Data 110-89-4(Hazardous Substances Data)
LD50 orally in rats: 0.52 ml/kg (Smyth)

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