1086391-06-1

473416-12-5

1086391-06-1

General procedure for the synthesis of methyl 3-bromo-1H-indazole-5-carboxylate from methyl 1H-indazole-5-carboxylate: a mixture of methyl 1H-indazole-5-carboxylate (1.7 g, 0.01 mol) with N-bromosuccinimide (NBS, 2.1 g, 0.012 mol) in tetrahydrofuran (THF, 10 ml) was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to give a residue. To the residue was added dichloromethane (DCM, 5 ml), stirred for 30 min and filtered to give methyl 3-bromo-1H-indazole-5-carboxylate (1.9 g, 80% yield) as a light yellow solid.