1008119-83-2

3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide is also known as JM6. Studies have shown JM6 participates in the inhibitory effects towards kynurenine 3-mono oxygenase in its activities in blood ameliorates neurodegeneration.

3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide is also known as JM6. Studies have shown JM6 participates in the inhibitory effects towards kynurenine 3-monooxygenase in its activities in blood ameliorates neurodegeneration.

JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) th at increases kynurenic acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficitsanxiety-related behaviorand synaptic loss in mouse model of Alzheimer disease.