ChemicalBook CAS DataBase List 1006378-90-0

1006378-90-0

Name	p38 MAPK-IN-1
CAS	1006378-90-0
Molecular Formula	C21H14F2N2O
MDL Number	MFCD28900744
Molecular Weight	348.35
MOL File	1006378-90-0.mol

Chemical Properties

Boiling point	527.0±50.0 °C(Predicted)
density	1.27±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 8.33 mg/mL (23.84 mM)
form	Solid
pka	0.26±0.40(Predicted)
color	Off-white to yellow

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	2933998090

Hazard Information

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Animal Model:	Male wistar rats^[1]
Dosage:	10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis)
Administration:	Po and iv
Result:	Had a t_1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C_max of 5.3 μM for po.

1006378-90-0

Chemical Properties

Safety Data

Hazard Information

Uses

in vivo

IC 50

storage

References

Supplier