Ethylenglykolmonophenylether

Bezeichnung:Ethylenglykolmonophenylether

CAS-Nr122-99-6

Englisch Name:2-Phenoxyethanol

CBNumberCB9852958

SummenformelC8H10O2

Molgewicht138.16

MOL-Datei122-99-6.mol

Synonyma

2-Phenoxyethanol

Ethylenglykolmonophenylether

Phenylcellosolve

Ethylenglykolmonophenylether physikalisch-chemischer Eigenschaften

Schmelzpunkt	11-13 °C (lit.)
Siedepunkt	247 °C (lit.)
Dichte	1.102 g/mL at 25 °C (lit.)
Dampfdichte	4.8 (vs air)
Dampfdruck	0.01 mm Hg ( 20 °C)
FEMA	4620 \| 2-PHENOXYETHANOL
Brechungsindex	n20/D 1.539
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	soluble, clear, colorless to very faintly yellow
pka	14.36±0.10(Predicted)
Aggregatzustand	Liquid
Wichte	1.109 (20/4℃)
Farbe	Clear colorless
Geruch (Odor)	Faint aromatic odor
Säure-Base-Indikators(pH-Indikatoren)	7 at 10 g/l at 23 °C
PH	7 (10g/l, H2O, 23℃)
Explosionsgrenze	1.4-9.0%(V)
Geruchsart	floral
Wasserlöslichkeit	30 g/L (20 ºC)
Merck	14,7257
BRN	1364011
InChIKey	QCDWFXQBSFUVSP-UHFFFAOYSA-N
LogP	1.2 at 23℃
CAS Datenbank	122-99-6(CAS DataBase Reference)
NIST chemische Informationen	2-Phenoxyethanol(122-99-6)
EPA chemische Informationen	Ethylene glycol monophenyl ether (122-99-6)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36-R36-R22
S-Sätze:	26-S26
WGK Germany	1
RTECS-Nr.	KM0350000
Selbstentzündungstemperatur	535 °C DIN 51794
Hazard Note	Irritant
TSCA	Yes
HS Code	29094990
Giftige Stoffe Daten	122-99-6(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Gefahreninformationscode (GHS)

2-Phenoxyethanol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
öLIGE FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: 20 ppm, 110 mg/m? Spitzenbegrenzung: überschreitungsfaktor I(2); Hautresorption; Schwangerschaft: Gruppe C; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut, und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege. Möglich sind Auswirkungen auf das Zentralnervensystem und das periphere Nervensystem mit nachfolgenden Funktionsstörungen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Die Flüssigkeit entfettet die Haut. Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgenden Funktionsstörungen.
LECKAGE
Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
Chemische Eigenschaften
clear colorless liquid
Chemische Eigenschaften
Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.
Charakteristisch
Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.
Verwenden
Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.
Verwenden
Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.
Verwenden
phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.
Verwenden
Antimicrobial preservative; also used topically in treatment of bacterial infections.
Vorbereitung Methode
Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.
Definition
ChEBI: 2-phenoxyethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group. It has a role as an antiinfective agent and a central nervous system depressant. It is a primary alcohol, a glycol ether and an aromatic ether. It is functionally related to a phenol.
Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 1356, 1975 DOI: 10.1021/jo00897a043
Allgemeine Beschreibung
Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.
Air & Water Reaktionen
Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.
Reaktivität anzeigen
2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.
Health Hazard
May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.
Brandgefahr
2-Phenoxyethanol is combustible.
Flammability and Explosibility
Not classified
Pharmazeutische Anwendungen
Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,
Industrielle Verwendung
2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).
Kontakt-Allergie
Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.
Sicherheitsprofil
Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.
Sicherheit(Safety)
Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD₅₀ (rabbit, skin): 5 g/kg
LD₅₀ (rat, oral): 1.26 g/kg
Lager
Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.
Inkompatibilitäten
The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

2-Phenoxyethanol Upstream-Materialien And Downstream Produkte

Ethylenglykolmonophenylether Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

122-99-6, 2-Phenoxyethanol Verwandte Suche:

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