L-2-Amino-3-methylbutan-1-ol

Bezeichnung:L-2-Amino-3-methylbutan-1-ol

CAS-Nr2026-48-4

Englisch Name:(S)-(+)-2-Amino-3-methyl-1-butanol

CBNumberCB9319657

SummenformelC5H13NO

Molgewicht103.16

MOL-Datei2026-48-4.mol

Synonyma

L-2-Amino-3-methylbutan-1-ol

L-2-Amino-3-methylbutan-1-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	30-34 °C
Siedepunkt	81 °C8 mm Hg(lit.)
alpha	16 º (c=10,EtOH)
Dichte	0.926 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.4548(lit.)
Flammpunkt	196 °F
storage temp.	Store at +2°C to +8°C.
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	12.82±0.10(Predicted)
Aggregatzustand	Liquid After Melting
Farbe	Clear slightly yellow
Optische Aktivität	[α]25/D +10°, c = 10 in H2O
Wasserlöslichkeit	Soluble in water.
Sensitive	Air Sensitive
BRN	1719137
InChIKey	NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS Datenbank	2026-48-4(CAS DataBase Reference)
NIST chemische Informationen	(S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36-36/37/38
S-Sätze:	26-24/25-36
WGK Germany	3
F	10-23
HazardClass	IRRITANT
HS Code	29221980

Gefahreninformationscode (GHS)

(S)-(+)-2-Amino-3-methyl-1-butanol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:
- Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
- Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.
Verwenden
L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.
läuterung methode
Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

(S)-(+)-2-Amino-3-methyl-1-butanol Upstream-Materialien And Downstream Produkte

L-2-Amino-3-methylbutan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2026-48-4, (S)-(+)-2-Amino-3-methyl-1-butanol Verwandte Suche:

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