Torin 1

$28 - $4500

Product nameTorin 1
Cas No1222998-36-8
MFC35H28F3N5O2
MW607.62
MDL NumberMFCD18782653

Synonyms

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE;Torin 1;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-;1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one Torin 1;Torin 1 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one;Torin 1, >=98%

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Price

62 prices

Brand less more

Sigma-Aldrich Cayman Chemical Arctom Crysdot ACHEMBLOCK Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Axon Medchem Medical Isotopes, Inc. ChemScene Biosynth DC Chemicals
Package less more

1unit 10.00mg 25.00mg 50.00mg 10mm*1mlindmso 200mg 250mg 500mg 5mg 10mg 25mg 50mg 1g 100mg 10 50

Clear All Done

Brand	Packaging	Price	Product name
ACHEMBLOCK 10730	5MG	$75	Torin 1
ACHEMBLOCK 10730	5MG	$75	Torin 1
ACHEMBLOCK 10730	25MG	$215	Torin 1
ACHEMBLOCK 10730	25MG	$215	Torin 1
ACHEMBLOCK 10730	100MG	$650	Torin 1
ACHEMBLOCK 10730	100MG	$650	Torin 1
ACHEMBLOCK 10730	1G	$2150	Torin 1
ACHEMBLOCK 10730	1G	$2150	Torin 1
AK Scientific Y0294	50mg	$640	Torin1
AK Scientific Y0294	10mg	$218	Torin1

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Properties

Melting point	>223°C (dec.)
Boiling point	817.2±65.0 °C(Predicted)
Density	1.362
storage temp.	+2C to +8C
solubility	Soluble in DMSO (up to 8 mg/ml).
form	Yellowish-white powder
pka	4.19±0.20(Predicted)
color	White or off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey	AKCRNFFTGXBONI-UHFFFAOYSA-N
SMILES	N1(C2=CC=C(N3CCN(C(=O)CC)CC3)C(C(F)(F)F)=C2)C2=C(C=NC3=CC=C(C4=CC5C(N=C4)=CC=CC=5)C=C32)C=CC1=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H320：Causes eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.

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Suppliers and manufacturers

career henan chemical co

$2.00/1kg

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

CAS:1222998-36-8
ATK CHEMICAL COMPANY LIMITED
Biochempartner
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.

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