TH588

$32 - $3150

Product nameTH588
Cas No1609960-31-7
MFC13H12Cl2N4
MW295.17
MDL NumberMFCD28963908

Synonyms

N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;TH588(TH-588);6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine;TH 588;TH-588;TH588;CS-1701;TH588, >98%

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Price

58 prices

Brand less more

Sigma-Aldrich Cayman Chemical Arctom Chemenu Crysdot ACHEMBLOCK AvaChem Tocris TRC ApexBio Technology Matrix Scientific AK Scientific Ark Pharm ChemScene DC Chemicals
Package less more

50mg 10mm(in1mldmso) 25 100mg 10mm*1mlindmso 1mg 5mg 10mg 25mg 5 1g 10mm*1mlindmso(solid+solvent) 250mg 1.00g 5g 10mm*1mlindmso(solution) 5.00g

Clear All Done

Brand	Packaging	Price	Product name
ACHEMBLOCK O33860	25MG	$130	TH588
ACHEMBLOCK O33860	100MG	$340	TH588
ACHEMBLOCK O33860	1G	$975	TH588
AK Scientific 6084DW	1mg	$133	N~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine
AK Scientific SYN5087	10mg	$160	TH588
ApexBio Technology B5845	25mg	$154	TH588
ApexBio Technology B5845	50mg	$240	TH588
ApexBio Technology B5845	50mg	$264	TH588
ApexBio Technology B5845	5mg	$66	TH588
ApexBio Technology B5845	10mM(in1mLDMSO)	$72	TH588

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Properties

Boiling point	545.7±60.0 °C(Predicted)
Density	1.505±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 5 mg/ml).
form	powder
pka	5.90±0.10(Predicted)
color	white to light brown
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI	1S/C13H12Cl2N4.ClH/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10;/h1-3,6-7H,4-5H2,(H3,16,17,18,19);1H
InChIKey	FBHMEHNWFXCSKE-UHFFFAOYSA-N
SMILES	ClC1=CC=CC(C2=NC(N)=NC(NC3CC3)=C2)=C1Cl.Cl

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Activein vitroandin vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4

Related product price

Lenvatinib $5-1410 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- $30-854 446859-33-2 $26-4788

Suppliers and manufacturers

career henan chemical co

$1.00/1KG

N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dic

CAS:1609960-31-7
TargetMol Chemicals Inc.

$57.00/5mg

TH588

CAS:1609960-31-7
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