Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice. Sedanolide inhibits cyclooxygenases-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 μg/ml. It is mosquitocidal, nematicidal, and antifungal but shows no cytotoxicity against normal mammalian cells.
