PLX647

$60 - $1600

Product namePLX647
Cas No873786-09-5
MFC21H17F3N4
MW382.38
MDL NumberMFCD28100808

Synonyms

PLX647;PLC647;5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine;[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine;2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-;PLX 647;PLX-647;CS-1696;5-({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[4-(trifluoromethyl)phenyl]methyl}pyridin-2-amine

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Price

40 prices

Brand less more

Crysdot Arctom ChemScene ApexBio Technology TRC Cayman Chemical aablocks Biosynth ACHEMBLOCK Chemenu DC Chemicals Usbiological
Package less more

10mm(in1mldmso) 5mg 10mg 25mg 50mg 100mg 10mm*1mlindmso(solution) 250mg 1g 10mm*1mlindmso(solid+solvent)

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA00GU2U	5mg	$107	PLX647
aablocks AA00GU2U	10mg	$185	PLX647
aablocks AA00GU2U	25mg	$370	PLX647
aablocks AA00GU2U	50mg	$598	PLX647
aablocks AA00GU2U	100mg	$1002	PLX647
ACHEMBLOCK AD264412	250MG	$700	PLX647
ACHEMBLOCK AD264412	100MG	$350	PLX647
ApexBio Technology B5816	10mg	$116	PLX647
ApexBio Technology B5816	10mM(in 1mL DMSO)	$90	PLX647
ApexBio Technology B5816	10mM(in1mLDMSO)	$99	PLX647

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Properties

Density	1.358±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	13.73±0.40(Predicted)
color	white to beige

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

PLX647 is a dual inhibitor of the receptor tyrosine kinases FMS and KIT (IC₅₀s = 28 and 16 nM, respectively). It is selective for FMS and KIT but does inhibit FLT3 and KDR (IC₅₀s = 91 and 130 nM, respectively) in a panel of 400 kinases at a concentration of 1 μM. PLX647 inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC₅₀s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells that express endogenous FMS and KIT, respectively (IC₅₀s = 380 and 230 nM, respectively). It has no effect on HEK293T or HepG2 cells that lack FMS and KIT (IC₅₀ = >50 μM) or Ba/F3 cells overexpressing KDR (IC₅₀ = >5 μM). PLX647 also inhibits differentiation of human osteoclast precursor cells (IC₅₀ = 170 nM). In vivo, PLX647 (40 mg/kg) reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release. It reduces mast cell degranulation in a mouse model of passive cutaneous anaphylaxis (PCA) and inhibits bone destruction and delays disease progression in a mouse model of collagen-induced arthritis (CIA). PLX647 also reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$35.00

PLX647

CAS:873786-09-5
ATK CHEMICAL COMPANY LIMITED
TopScience Biochemical
TargetMol Chemicals Inc.
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd

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