PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14. The compound has been used to study MMP’s contribution to the dilation of the left ventricle, that results in left ventricle dysfunction. The MMP inhibitor has demonstrated countering of high energy phosphate depletion in subacute heart failure models.
