PricePropertiesSafety InformationDescription
ChemicalBook > CAS DataBase List > PD 0325901

PD 0325901

  • $8 - $1680
  • Product name:PD 0325901
  • CAS:391210-10-9
  • MF: C16H14F3IN2O4
  • MW:482.19
  • EINECS:687-152-7
  • MDL Number:MFCD08435926
  • Synonyms:N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE;PD 0325901;(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide;PD-0235901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be;PD325901;N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901
Price
  • Brand:Sigma-Aldrich
  • Product number:444966
  • Product nameMEK1/2 Inhibitor III
  • Purity:
  • Packaging:5mg
  • Price:$173.9
  • Updated:2021/12/16 16:57:17
  • Buy:Buy
  • Brand:Sigma-Aldrich
  • Product number:444968
  • Product nameInSolution? MEK1/2 Inhibitor III, PD0325901
  • Purity:
  • Packaging:5mg
  • Price:$188
  • Updated:2021/12/16 16:57:17
  • Buy:Buy
  • Brand:Tocris
  • Product number:4192
  • Product namePD 0325901
  • Purity:≥99%(HPLC)
  • Packaging:50
  • Price:$1156
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:Tocris
  • Product number:4192
  • Product namePD 0325901
  • Purity:≥99%(HPLC)
  • Packaging:10
  • Price:$276
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
  • Brand:Usbiological
  • Product number:474149
  • Product namePD 0325901
  • Purity:
  • Packaging:100mg
  • Price:$1168
  • Updated:2021/12/16 17:17:49
  • Buy:Buy
Properties
  • Melting point:112-114°C
  • Density 1.817±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: soluble20mg/mL, clear
  • form White to off-white solid
  • pka13.45±0.20(Predicted)
  • color white to off-white
  • optical activity[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
  • InChIKeySUDAHWBOROXANE-SECBINFHSA-N
Safety Information
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements
  • H301:Toxic if swalloed
  • H373:May cause damage to organs through prolonged or repeated exposure
  • H413:May cause long lasting harmful effects to aquatic life
  • Precautionary statements
  • P260:Do not breathe dust/fume/gas/mist/vapours/spray.

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation with 1 μM PD 0325901 combined with 3 μM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.


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