P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 ~ 2.7 g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 g/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 ~ 5 g/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
