P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Merck earned its first global
approval for omarigliptin in Japan in 2015, and phase III
development is ongoing in other countries around the globe for
this interesting small molecule DPP-4 inhibitor. Interestingly,
while most DPP-4 inhibitors used to treat type 2 DM require
daily administration, omarigliptin is a weekly treatment. The
process-scale synthesis of omarigliptin has been nicely
described in an October 2015 paper from the Merck process
group.