ML 141

$23 - $2193

Product nameML 141
Cas No71203-35-5
MFC22H21N3O3S
MW407.49
MDL NumberMFCD05987165

Synonyms

4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide;CID-2950007;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide;ML 141;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZI<WBR />NE TRIHYDROCHLORIDE

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Price

54 prices

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aablocks Ambeed Cayman Chemical ChemScene CSNpharm ApexBio Technology ACHEMBLOCK AK Scientific American Custom Chemicals Corporation Sigma-Aldrich DC Chemicals Tocris Usbiological Crysdot Chemenu TRC Biosynth
Package less more

25mg 500mg 250mg 10 50 1g 10mm*1mlindmso 1mg 2mg 5mg 10mg 50mg 100mg

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Brand	Packaging	Price	Product name
aablocks AA00FBYV	1mg	$23	ML141
aablocks AA00FBYV	5mg	$49	ML141
aablocks AA00FBYV	10mg	$67	ML141
aablocks AA00FBYV	50mg	$113	ML141
ACHEMBLOCK Q65502	100MG	$110	4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
ACHEMBLOCK Q65502	1G	$560	4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
AK Scientific 2551AH	2mg	$113	4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
Ambeed A201975	10mg	$84	ML141
Ambeed A201975	5mg	$62	ML141
Ambeed A201975	1mg	$28	ML141

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Properties

Melting point	216 °C(Solv: ethanol (64-17-5))
Boiling point	622.9±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL (warmed, clear solution)
pka	10.39±0.10(Predicted)
form	Yellow-white solid
color	white to beige
InChI	1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27)
InChIKey	QBNZBMVRFYREHK-UHFFFAOYSA-N
SMILES	NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H320：Causes eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 μM) with no inhibitory action against Rho, Ras, Rab, or Rac. It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 μM). ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin. It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.

Related product price

754240-09-0 $23-1900 Entinostat $12-4500 NSC 23766 (hydrochloride) $19-1900

Suppliers and manufacturers

TargetMol Chemicals Inc.

$33.00

ML141

CAS:71203-35-5
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd

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