ML277

$23 - $2100

Product nameML277
Cas No1401242-74-7
MFC23H25N3O4S2
MW471.59
MDL NumberMFCD28133374

Synonyms

VU0458298-2, VU0458298-3;ML277;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;CID-53347902;ML277;ML 277; ML-277;(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

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Price

50 prices

Brand less more

aablocks Cayman Chemical Crysdot Ambeed Axon Medchem ChemScene ApexBio Technology TRC Sigma-Aldrich AK Scientific DC Chemicals Tocris ACHEMBLOCK Usbiological
Package less more

250mg 10 100mg 50 1g 10mm*1mlindmso 1mg 5mg 10mg 25mg 50mg

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA001BZ3	1mg	$23	ML 277
aablocks AA001BZ3	5mg	$28	ML 277
aablocks AA001BZ3	10mg	$49	ML 277
aablocks AA001BZ3	25mg	$107	ML 277
aablocks AA001BZ3	50mg	$166	ML 277
aablocks AA001BZ3	100mg	$245	ML 277
aablocks AA001BZ3	250mg	$346	ML 277
ACHEMBLOCK U127649	250MG	$275	ML277
ACHEMBLOCK U127649	100MG	$255	ML277
AK Scientific SYN5303	10mg	$160	ML277

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Properties

Density	1.341±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 5 mg/ml
pka	8.37±0.70(Predicted)
form	powder
color	white to beige
InChIKey	UKSXJENCMIVQMU-HXUWFJFHSA-N
SMILES	COc1ccc(cc1)-c2cnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c4ccc(C)cc4)s2

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

Related product price

ML364 $15-1800 877636-42-5 $16-1920 1378872-36-6 $10-1350

Suppliers and manufacturers

career henan chemical co

$1.00/1KG

(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide

CAS:1401242-74-7
TargetMol Chemicals Inc.

$71.00/5mg

ML277

CAS:1401242-74-7
ATK CHEMICAL COMPANY LIMITED
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Zibo Hangyu Biotechnology Development Co., Ltd

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