LAZABEMIDE

$33 - $848.93

Product nameLAZABEMIDE
Cas No103878-84-8
MFC8H10ClN3O
MW199.64
MDL NumberMFCD00865419

Synonyms

LAZABEMIDE;LAZABEMIDE HYDROCHLORIDE;N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide;Ro-19-6327;2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-;Ro 19-6327/000;Lazabemide hydrate;N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate

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Price

20 prices

Brand less more

Sigma-Aldrich Cayman Chemical AHH CSNpharm Tocris Usbiological ChemScene American Custom Chemicals Corporation DC Chemicals
Package less more

50 5mg 10mg 25mg 50mg 10 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
AHH MT-53148	1g	$310	Lazabemide
American Custom Chemicals Corporation INB0004993	5MG	$144.1	LAZABEMIDE
American Custom Chemicals Corporation INB0004993	1G	$848.93	LAZABEMIDE
Cayman Chemical 11640	5mg	$33	Lazabemide
Cayman Chemical 11640	5mg	$37	Lazabemide
Cayman Chemical 11640	10mg	$62	Lazabemide
Cayman Chemical 11640	10mg	$69	Lazabemide
Cayman Chemical 11640	50mg	$254	Lazabemide
Cayman Chemical 11640	50mg	$280	Lazabemide
ChemScene CS-4008	10mg	$60	Lazabemide

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Properties

Boiling point	397.4±37.0 °C(Predicted)
Density	1.286±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: ≥22mg/mL
pka	12.90±0.46(Predicted)
form	powder
color	white to tan
InChI	1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2
InChIKey	JYWYNPKXSLPWGV-UHFFFAOYSA-N
SMILES	O.NCCNC(=O)c1ccc(Cl)cn1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Monoamine oxidases, MAO-A and MAO-B, regulate the intracellular concentrations of biogenic monoamines such as 5-hydroxytryptamine and dopamine via oxidative deamination. Inhibitors of MAO-A are widely used for the therapy of affective disorders, whereas MAO-B inhibitors have clinical efficacy in the treatment of Parkinson’s disease. Lazabemide is a reversible inhibitor of monoamine oxidase B (MAO-B) with IC50 values of 0.48 and 1.5 μM measured in platelets of human subjects ages 19-36 and 60-78, respectively. It is structurally similar to the MAO-B preferential substrate phenylethylamine and can be oxidized by MAO-B, forming tightly, but reversibly, bound adducts with the active site of the enzyme. The selectivity of lazabemide for MAO-B inhibition has been demonstrated in both in vitro and ex vivo conditions and it was evaluated in clinical trials for possible neuroprotective actions in the treatment of Parkinson’s disease.

Related product price

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Suppliers and manufacturers

career henan chemical co

$7.00/1KG

LAZABEMIDE

CAS:103878-84-8
TargetMol Chemicals Inc.

$50.00/10mg

LAZABEMIDE

CAS:103878-84-8
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Finetech Industry Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Chongqing Chemdad Co., Ltd

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PYRIDINE-2-CARBOXYLIC ACID (2-AMINO-ETHYL)-AMIDE
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LAZABEMIDE

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