Chemical Properties
Lazabemide Monohydrochloride: C8Hl0ClN3OHCl.[103878-83-7]. Crystallized from methanol-ether, melting point 193-195°C. Partition coefficient (n-octanol pulse): about 0.1. pKa 8.9. acute toxicity LD50 mice (mg/kg): 1000~2000 orally.
Uses
Treatment of Alzheimer’s disease.
Uses
Lazabemide hydrate may be used in cell signaling studies.
brand name
Tempium (Hoffmann-LaRoche).
Biochem/physiol Actions
Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation.