Ferulenol is a prenylated 4-hydroxycoumarin first isolated from F. communis that demonstrates potent antimycobacterial activity. It does not directly affect blood coagulation but at concentrations less than 100 nM has been shown to impair factor X biosynthesis. Ferulenol has also been shown to stimulate tubulin polymerization in vitro, rearranging cellular microtubule networks into short fibers and altering nuclear morphology, which leads to cytotoxicity in various human tumor cell lines. Ferulenol is reported to disrupt oxidative phosphorylation, inhibiting succinate ubiquinone reductase without altering succinate dehydrogenase activity of complex II of the electron chain transport system.
