DAPH is a tyrosine kinase inhibitor, which suppresses and reverses the formation of Aβ42 fibers in neurons. DAPH displays specificity towards the EGFR kinase3 receptor. Studies suggest that DAPH can attenuate phenylephrine-induced endothelium contraction in aortic rings. It is known that Aβ42 proteins are composed of β sheets that are arranged parallel to the fibril axis and are several micrometers in length. DAPH is a useful tool in inhibiting these proteins because it can disrupt fibril formation which is vital for β sheet formation.
