insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form
White to off-white powder.
Description
Compound 56 is a highly potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 0.006 nM). It has been used to inhibit EGFR activity in pancreatic cancer cell lines and to induce the differentiation of rat mesenchymal stem cells.