GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat) (trifluoroacetate salt)

Glucagon-like peptide 1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) (Item No. 24460) that is produced via cleavage of preproglucagon in the pancreas and intestine.1 It binds to βTC-1 and RIN 1027-B2 cells (Kds = 3.3 and 3.5 nM, respectively) and enhances insulin secretion in βTC-1 cells in a concentration- and glucose-dependent manner.2 Ex vivo, GLP-1 (7-37) stimulates insulin release from perfused rat pancreas.1 GLP-1 (7-37) increases plasma insulin concentrations by greater than 50% as compared to vehicle control in response to hyperglycemia in rats when administered at a dose of 15 pmol/min/kg for five days.3WARNING This product is not for human or veterinary use.