Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II (Item No. 17150) by angiotensin-converting enzyme (ACE).1 It binds to angiotensin receptors in human myometrium membrane preparations (Kd = 11.2 nM) and increases renal vascular resistance in isolated rat kidney (EC50 = 10.5 nM).2,3 In vivo, angiotensin I (5 μg/kg, i.c.v.) increases mean arterial pressure (MAP) and plasma arginine vasopressin (AVP) level in fetal ewes.4WARNING This product is not for human or veterinary use.
