Angiotensin I (human, rat, mouse) (trifluoroacetate salt)

Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II (Item No. 17150) by angiotensin-converting enzyme (ACE).1 It binds to angiotensin receptors in human myometrium membrane preparations (Kd = 11.2 nM) and increases renal vascular resistance in isolated rat kidney (EC50 = 10.5 nM).2,3 In vivo, angiotensin I (5 μg/kg, i.c.v.) increases mean arterial pressure (MAP) and plasma arginine vasopressin (AVP) level in fetal ewes.4WARNING This product is not for human or veterinary use.

[1] ZHENLONG CHEN. Hydrolysis of angiotensin peptides by human angiotensin I-converting enzyme and the resensitization of B2 kinin receptors.[J]. Hypertension, 2005, 46 6: 1368-1373. DOI: 10.1161/01.hyp.0000188905.20884.63
[2] RICHARD BOULEY. N- and C-terminal structure–activity study of angiotensin II on the angiotensin AT2 receptor[J]. European journal of pharmacology, 1998, 343 2: Pages 323-331. DOI: 10.1016/s0014-2999(97)01549-5
[3] M SCHMIDT. Effect of angiotensin converting enzyme inhibitors on the vasoconstrictor action of angiotensin I on isolated rat kidney.[J]. Journal of Cardiovascular Pharmacology, 1986, 8 Suppl 10: S100-5. DOI: 10.1097/00005344-198600101-00018
[4] LIJUN SHI. Central angiotensin I increases fetal AVP neuron activity and pressor responses.[J]. American journal of physiology. Endocrinology and metabolism, 2010, 298 6: E1274-82. DOI: 10.1152/ajpendo.00060.2010