Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1,2 The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone.3 ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).3,4 It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively.1,5 Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.6WARNING This product is not for human or veterinary use.
