SANT-2 is a cell permeable antagonist of the Smo protein function and an inhibitor of SAG activity. SANT-2 has been used as al tool to study the Hedgehog (Hh) signaling pathway and to explore therapeutic uses for inhibitors of Smo. Because hedgehog over activation of has been observed among some cancers, SANT-2 and other Smo antagonists are being studied for their antitumor activities.
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