Hh-Ag 1.3

$117 - $1140

Product nameHh-Ag 1.3
Cas No364590-63-6
MFC28H28ClN3OS
MW490.06
EINECS-0
MDL NumberMFCD14636155

Synonyms

3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Smoothened Agonist, HCl;SAG . dihydrochloride (water soluble);Hh-Ag 1.3;3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride;Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-;Frizzled6 agonist SAG1.3;(Rac)-SAG

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Price

2 prices

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Sigma-Aldrich
Package less more

1mg 5mg

Clear All Done

Brand	Packaging	Price	Product name
Sigma-Aldrich 566660	1mg	$397	Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
Sigma-Aldrich 566660	5mg	$1140	Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem

Properties

Boiling point	688.6±55.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 10mg/mL water: 25mg/mL
form	White to off-white solid.
pka	10+-.0.40(Predicted)
color	light yellow
Water Solubility	Soluble in water.
Sensitive	Light Sensitive & Hygroscopic
InChIKey	IYXUQUYRWPGIQL-UHFFFAOYSA-N
SMILES	[s]1c2c(c(c1C(=O)N(C5CCC(CC5)NC)Cc3cc(ccc3)c4ccncc4)Cl)cccc2.Cl.Cl.O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.

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Suppliers and manufacturers

Aladdin Scientific
DAYANG CHEM (HANGZHOU) CO.,LTD
Shanghai Witofly Chemical Co.,Ltd
Quality Control Solutions Ltd.
Aikon International Limited
Nanjing crow LuNing pharmaceutical technology co., LTD
Energy Chemical
Nantong Hanfang Biotechnology Co. , Ltd.
TargetMol Chemicals Inc.
Adipogen Life Sciences

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