KI16425

Описание

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA_1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA₁ and LPA₃. It exhibits K_i values of 0.34, 6.5, and 0.93 μM for the human LPA₁, LPA₂, and LPA₃ receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.

Использование

Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.

Биохимия/физиол Действия

Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.