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Megestrol acetate
- русский язык имя
- английское имяMegestrol acetate
- CAS №595-33-5
- CBNumberCB9434253
- ФормулаC24H32O4
- мольный вес384.51
- EINECS209-864-5
- номер MDLMFCD00056470
- файл Mol595-33-5.mol
Температура плавления | 214°C |
альфа | D24 +5° (chloroform) |
Температура кипения | 431.17°C (rough estimate) |
плотность | 1.0474 (rough estimate) |
показатель преломления | 11 ° (C=2, CHCl3) |
температура хранения | Sealed in dry,Room Temperature |
растворимость | Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol. |
форма | Solid |
цвет | White |
Мерк | 14,5805 |
БРН | 1917291 |
ИнЧИКей | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
SMILES | C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)C=C2C |
Справочник по базе данных CAS | 595-33-5(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | megestrol acetate |
FDA UNII | TJ2M0FR8ES |
Словарь наркотиков NCI | megestrol acetate |
Предложение 65 Список | Megestrol Acetate |
Справочник по химии NIST | Megestrol acetate(595-33-5) |
Система регистрации веществ EPA | Megestrol acetate (595-33-5) |
Коды опасности | Xn | |||||||||
Заявления о рисках | 40-48 | |||||||||
Заявления о безопасности | 22-24/25 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | TU4075000 | |||||||||
кода HS | 29372390 | |||||||||
Токсичность | LD50 intravenous in mouse: 56mg/kg | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H360FD:Может отрицательно повлиять на способность к деторождению. Может отрицательно повлиять на неродившегося ребенка.
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оператор предупредительных мер
P201:Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P202:Перед использованием ознакомиться с инструкциями по технике безопасности.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P308+P313:ПРИ подозрении на возможность воздействия обратиться за медицинской помощью.
P405:Хранить в недоступном для посторонних месте.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Megestrol acetate химические свойства, назначение, производство
Описание
Megestrol Acetate is the acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. It is frequently used in the treatment of patients with metastatic breast cancer. It is generally well tolerated, except that it may cause undesirable weight gain. Subsequently, it was shown that megestrol acetate produced weight gain in a variety of cachectic cancer patients. Significant reduction inserum levels of IL-1a and b,IL-2,IL-6, and TNF-o were observed in cancer patientstreated with megestrol acetate which may bear on the mechanism of improved appetite and body weight gain.It has also been postulated that the effect is, at least in part,mediated by NPY,a potent central appetite stimulant.Химические свойства
Crystalline SolidИспользование
Megestrol acetate (Megace), a semi-synthetic progestational steroid, is the most effective known appetite stimulant at present. Previously used in patients with cancer and acquired immunodeficiency syndrome, only a few studies have considered the applicability of this drug in malnourished older persons.Megestrol acetate is useful if profound anorexia is the main manifestation of cachexia and if expected survival is weeks to months. Megace has been shown to significantly increase appetite, but not survival. In patients with a shorter predicted survival, a brief course of corticosteroids may be useful to stimulate appetite and have positive effects on nausea, pain, and asthenia.
Общее описание
Megestrol acetate, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), is a progestin used primarily for the palliativemanagement of recurrent, inoperable, or metastatic endometrialor breast carcinoma. Megestrol acetate has also beenindicated for appetite enhancement in patients with AIDS.The biochemical basis for this use of megestrol is unclear.Клиническое использование
Progestin activity is further enhanced when a double bond is introduced between positions 6 and 7, as is found in megestrol acetate. Megestrol is used primarily in the treatment of breast and endometrial carcinomas and in postmenopausal women with advanced hormone-dependent carcinoma.Профиль безопасности
Suspected carcinogen with experimental carcinogenic and teratogenic data. Poison by intravenous route. Human reproductive effects bp ingestion and implant routes: effects on ovaries and fallopian tubes, menstrual cycle changes, and female fertility index changes. Mutation data reported. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA proprietary drug used to treat endometriosis and breast cancer. A steroid.Метаболизм
Less than 10% of an oral dose undergoes metabolism. Several major metabolites appear in the urine (e.g., 2-hydroxy and 6-hydroxymethyl megestrol and their glucuronide conjugates).Megestrol acetate запасные части и сырье
Megestrol acetate поставщик
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