![ChemicalBook](https://m.chemicalbook.com/Scripts/New/img/logo.png)
![структурированное изображение](/CAS/GIF/475-31-0.gif)
Glycocholic acid
- русский язык имя
- английское имяGlycocholic acid
- CAS №475-31-0
- CBNumberCB8378590
- ФормулаC26H43NO6
- мольный вес465.63
- EINECS207-494-9
- номер MDLMFCD00065902
- файл Mol475-31-0.mol
химическое свойство
Температура плавления | 128°C |
Температура кипения | 568.76°C (rough estimate) |
плотность | 1.1336 (rough estimate) |
показатель преломления | 1.6000 (estimate) |
температура хранения | Refrigerator |
растворимость | methanol: 0.1 g/mL, clear, colorless |
форма | Solid |
пка | 4.4(at 25℃) |
цвет | White to Off-White |
Растворимость в воде | 329.9mg/L(20 ºC) |
Мерк | 13,4507 |
Стабильность | Hygroscopic |
ИнЧИКей | RFDAIACWWDREDC-NSPZZGDONA-N |
LogP | 1.650 |
Вещества, добавляемые в пищу (ранее EAFUS) | GLYCOCHOLIC ACID |
Специальный комитет по веществам GRAS | Glycocholic acid |
Справочник по базе данных CAS | 475-31-0(CAS DataBase Reference) |
FDA UNII | G59NX3I3RT |
Справочник по химии NIST | Glycocholic acid(475-31-0) |
больше
Коды опасности | N | |||||||||
Заявления о рисках | 51/53 | |||||||||
Заявления о безопасности | 61 | |||||||||
РИДАДР | UN 3077 9/PG 3 | |||||||||
WGK Германия | 3 | |||||||||
NFPA 704: |
|
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
предупреждение
-
вредная бумага
H302+H312+H332:Вредно при проглатывании, при попадании на кожу или при вдыхании.
-
оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
Glycocholic acid химические свойства, назначение, производство
Описание
Glycocholic acid is a glycine-conjugated form of the primary bile acid cholic acid and has roles in the emulsification of fats. It reduces expression of the gene encoding the farnesoid X receptor (FXR) and increases expression of the genes encoding the bile acid receptors TGR5 and S1PR2 in SNU-245 cells when used at a concentration of 1.6 μmol/ml. Glycocholic acid (250 μM) increases the intracellular accumulation and cytotoxicity of epirubicin in Caco-2 cells, as well as decreases expression of the genes encoding multidrug resistance protein 1 (MDR1), MDR-associated protein 1 (MRP1), and MRP2 when used alone or in combination with epirubicin. It increases absorption of epirubicin into everted sacs of rat ileum and jejunum when used at a concentration of 250 μM. The bile acid composition ratio of glycocholic acid is elevated in bile of patients with cholangiocarcinoma compared with patients with pancreatic cancer or benign biliary diseases. Serum levels of glycocholic acid are elevated in patients with hepatocellular carcinoma compared with healthy individuals.Химические свойства
Off-White SolidИспользование
Labelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt.Определение
ChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component.Методы очистки
Glycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.]Glycocholic acid запасные части и сырье
Glycocholic acid поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
---|---|---|---|---|
+8618523575427 | China | 49392 | 58 | |
18192627656 | China | 2999 | 58 | |
+86-17531190177; +8617531190177 |
China | 5873 | 58 | |
+86-027-59207850 | China | 5989 | 58 | |
+86-0533-2185556 +8617865335152 |
China | 10991 | 58 | |
+86-371-86557731 +86-13613820652 |
China | 20294 | 58 | |
+undefined86-15315557071 | China | 983 | 58 | |
China | 74 | 58 | ||
+8615383190639 | China | 1000 | 58 | |
+86-0371-55170693 +86-19937530512 |
China | 21667 | 55 |
Glycocholic acid Обзор)
1of3