DL-α-Difluoromethylornithine hydrochloride hydrate solid

английское имяDFMO
CAS №70052-12-9
CBNumberCB8373227
ФормулаC6H12F2N2O2
мольный вес182.17
номер MDLMFCD00221766
файл Mol70052-12-9.mol

химическое свойство

Температура плавления	138 °C
Температура кипения	347.0±42.0 °C(Predicted)
плотность	1.1800 (estimate)
температура хранения	Store at 0°C
растворимость	H₂O: >10 mg/mL, soluble
пка	1.22±0.44(Predicted)
форма	solid
цвет	white
Рейтинг продуктов питания EWG	1
Словарь онкологических терминов NCI	DFMO
FDA UNII	ZQN1G5V6SR

Заявления об опасности и безопасности

WGK Германия	3
Банк данных об опасных веществах	70052-12-9(Hazardous Substances Data)

DL-α-Difluoromethylornithine hydrochloride hydrate solid химические свойства, назначение, производство

Химические свойства

Off-white powder

Использование

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Общее описание

Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.

Биологическая активность

Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.

DL-α-Difluoromethylornithine hydrochloride hydrate solid поставщик

поставщик	телефон	страна	номенклатура продукции	благоприятные условия
BOC Sciences	16314854226; +16314854226	United States	19743	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	China	19915	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	China	25363	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58
Amadis Chemical Company Limited	571-89925085	China	131980	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	China	15848	69
LGM Pharma	1-(800)-881-8210	United States	2127	70
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988	China	1494	55

DL-α-Difluoromethylornithine hydrochloride hydrate solid Обзор)

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