DL-α-Difluoromethylornithine hydrochloride hydrate solid
- английское имяDFMO
- CAS №70052-12-9
- CBNumberCB8373227
- ФормулаC6H12F2N2O2
- мольный вес182.17
- номер MDLMFCD00221766
- файл Mol70052-12-9.mol
химическое свойство
| Температура плавления | 138 °C |
| Температура кипения | 347.0±42.0 °C(Predicted) |
| плотность | 1.1800 (estimate) |
| температура хранения | Store at 0°C |
| растворимость | H2O: >10 mg/mL, soluble |
| пка | 1.22±0.44(Predicted) |
| форма | solid |
| цвет | white |
| Рейтинг продуктов питания EWG | 1 |
| Словарь онкологических терминов NCI | DFMO |
| FDA UNII | ZQN1G5V6SR |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
| WGK Германия | 3 |
| Банк данных об опасных веществах | 70052-12-9(Hazardous Substances Data) |
DL-α-Difluoromethylornithine hydrochloride hydrate solid химические свойства, назначение, производство
Химические свойства
Off-white powderИспользование
DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.Общее описание
Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.Биологическая активность
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.DL-α-Difluoromethylornithine hydrochloride hydrate solid поставщик
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