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Клиохинол
- английское имяClioquinol
- CAS №130-26-7
- CBNumberCB7298550
- ФормулаC9H5ClINO
- мольный вес305.5
- EINECS204-984-4
- номер MDLMFCD00006787
- файл Mol130-26-7.mol
Температура плавления | 175-183 °C |
Температура кипения | 350.4±37.0 °C(Predicted) |
плотность | 1.8959 (estimate) |
давление пара | 0Pa at 25℃ |
температура хранения | 2-8°C |
растворимость | Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)). |
пка | pKa 8.12(50%aqEtOH t=35.0±0.1 I=0.00 N2atmosphere)(Approximate) |
форма | Solid |
цвет | Light Beige to Beige |
Растворимость в воде | <0.1 g/100 mL at 20 ºC |
Мерк | 14,5031 |
БРН | 153637 |
LogP | 1.523 at 24℃ |
Справочник по базе данных CAS | 130-26-7(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | 7BHQ856EJ5 |
Словарь наркотиков NCI | clioquinol |
Код УВД | D08AH30,D09AA10,G01AC02,P01AA02,P01AA52,S02AA05 |
Справочник по химии NIST | 5-Chloro-7-iodo-8-quinolinol(130-26-7) |
Система регистрации веществ EPA | Clioquinol (130-26-7) |
Коды опасности | T | |||||||||
Заявления о рисках | 25 | |||||||||
Заявления о безопасности | 36/37/39-45 | |||||||||
РИДАДР | UN 2811 6.1/PG 3 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | VC5075000 | |||||||||
TSCA | Yes | |||||||||
Класс опасности | 6.1(b) | |||||||||
Группа упаковки | III | |||||||||
кода HS | 2933492250 | |||||||||
Банк данных об опасных веществах | 130-26-7(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orally in cats: 400 mg/kg (Davis) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
H301:Токсично при проглатывании.
H317:При контакте с кожей может вызывать аллергическую реакцию.
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оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P264:После работы тщательно вымыть кожу.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Клиохинол химические свойства, назначение, производство
Химические свойства
Almost white, light yellow, brownish-yellow or yellowish-grey powder.Использование
Clioquinol is used as an anti-infective agent; antiamoebic agent; intravaginal trichomonacide; used to impregnate cotton bandages for antibacterial purposes; in animals as an intestinal anti-infective agent.Показания
Iodochlorhydroxyquin (Clioquinol), containing 40% iodine, was originally developed as a substitute for iodoform as an antiseptic dusting powder. Although its most effective use is in the treatment of amebiasis, it also has mild antibacterial and antifungal effects and may be used alone or with steroids in the treatment of eczematous and impetiginized processes and some dermatophyte, yeast, and Trichomonas infections. However, more specific agents are available. Because of neurotoxicity, the oral form of this drug has been withdrawn in the United States. A recent study demonstrating significant percutaneous absorption when applied to intact human skin raises concern regarding its topical use as well. The medication may stain the skin, hair, and clothing yellow and may induce contact allergy.Определение
ChEBI: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has al o been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.Всемирная организация здравоохранения(ВОЗ)
Clioquinol, a halogenated hydroxyquinoline derivative, was introduced into medicine around 1900 as a topical antiseptic and in 1934 oral preparations for the treatment of amoebic dysentery and simple diarrhoea became available. By 1964 its use in Japan had been associated with cases of sub-acute myelo-optic neuropathy (SMON) which reached epidemic proportions resulting in its withdrawal there in 1970. Although relatively few cases of SMON were documented elsewhere, clioquinol was subsequently withdrawn from use in many countries and placed under prescription control in others. It was phased out worldwide by the major manufacturer between 1983 and 1985 on grounds of obsolescence. No adequately controlled evidence was ever generated to demonstrate that clioquinol is effective in bacterial or viral diarrhoea. However, products containing clioquinol and related halogenated hydroxyquinolines continue to be used in some tropical and subtropical countries where amoebiasis remains endemic. Other amoebocides are preferred in the WHO Model List of Essential Drugs. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)Общее описание
Cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.Реакции воздуха и воды
Insoluble in water.Профиль реактивности
Clioquinol is incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides . Darkens on exposure to light.Пожароопасность
Flash point data for Clioquinol are not available; however, Clioquinol is probably combustible.Клиническое использование
5-Chloro-7-iodo-8-quinolinol, 5-chloro8-hydroxy-7-iodoquinoline, or iodochlorhydroxyquin (Vioform) occursas a spongy, light-sensitive, yellowish white powder that isinsoluble in water. Vioform was initially used as a substitutefor iodoform in the belief that it released iodine in the tissues.It has been used as a powder for many skin conditions,such as atopic dermatitis, eczema, psoriasis, and impetigo.A 3% ointment or cream has been used vaginally as a treatmentfor Trichomonas vaginalis vaginitis. The best use forVioform is in the topical treatment of fungal infections suchas athlete’s foot and jock itch. A combination with hydrocortisone(Vioform HC) is also available.Профиль безопасности
Poison by ingestion. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: change in central nervous system electrical function, optic nerve damage, and changes in vision. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, I-, and NOx.Методы очистки
It crystallises from AcOH or xylene and dry it at 70o in vacuo.[Beilstein 21 III/IV 1190.]Клиохинол запасные части и сырье
Клиохинол поставщик
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