Марбофлоксацин

Описание

Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml). It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 μg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively. In vivo, the administration of marbofloxacin (2 mg/kg, i.m.) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia. Oral marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%. Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.

Химические свойства

Crystalline Solid

Использование

Fluorinated quinolone antibacterial

Определение

ChEBI: A fluoroquinolone antibiotic that is 7-oxo-2,3-dihydro-7H-[1,3,4]oxadiazino[6,5,4-ij]quinoline substituted at positions 6, 9 and 10 by carboxy, fluoro and 4-methylpiperazin-1-yl groups, respectively. A synthetic, broad spect um bactericidal agent, it is used in veterinary medicine, although its mechanism of action is not thoroughly understood.

Побочные эффекты

The most common side effects of Marbofloxacin are vomiting, diarrhoea and loss of appetite. More serious side effects include cartilage abnormalities (which may cause difficulty walking), prolonged loss of appetite, incoordination, convulsions, depression, fever, rash, or difficulty breathing. Blindness and eye damage in cats has been a concern at high doses.