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АНЕКОРТАВА АЦЕТАТ (200 мг) F0E2980.997MG / MG (AI)
- английское имяAnecortave Acetate
- CAS №7753-60-8
- CBNumberCB5501441
- ФормулаC23H30O5
- мольный вес386.48
- EINECS231-812-5
- номер MDLMFCD00921393
- файл Mol7753-60-8.mol
химическое свойство
Температура плавления | 230-234°C |
альфа | D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3). |
Температура кипения | 551.8±50.0 °C(Predicted) |
плотность | 1.23±0.1 g/cm3(Predicted) |
температура хранения | -20°C Freezer |
растворимость | Chloroform (Slightly), Methanol (Slightly) |
форма | Solid |
пка | 12.47±0.60(Predicted) |
цвет | Off-White to Beige |
FDA UNII | Y0PC411K4T |
Код УВД | S01LA02 |
АНЕКОРТАВА АЦЕТАТ (200 мг) F0E2980.997MG / MG (AI) химические свойства, назначение, производство
Описание
Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.Химические свойства
Off-White SolidИспользование
As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.Ферментативный ингибитор
This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.АНЕКОРТАВА АЦЕТАТ (200 мг) F0E2980.997MG / MG (AI) запасные части и сырье
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АНЕКОРТАВА АЦЕТАТ (200 мг) F0E2980.997MG / MG (AI) поставщик
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