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Алклофенак
- английское имяALCLOFENAC
- CAS №22131-79-9
- CBNumberCB5491171
- ФормулаC11H11ClO3
- мольный вес226.66
- EINECS244-795-4
- номер MDLMFCD00071612
- файл Mol22131-79-9.mol
химическое свойство
Температура плавления | 90-91°C |
Температура кипения | 324.6°C (rough estimate) |
плотность | 1.2401 (rough estimate) |
показатель преломления | 1.4530 (estimate) |
температура хранения | Refrigerator |
растворимость | Chloroform (Slightly), Methanol (Slightly) |
пка | pKa 10.3 (Uncertain) |
форма | Solid |
цвет | Off-White to Pale Yellow |
Растворимость в воде | 13.1mg/L(25 ºC) |
FDA UNII | M9CP5H21N8 |
Код УВД | M01AB06 |
Токсичность | LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin) | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Алклофенак химические свойства, назначение, производство
Химические свойства
Off-White to Pale Yellow SolidИспользование
Analgesic; antipyretic; anti-inflammatory.Определение
ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r sh.Всемирная организация здравоохранения(ВОЗ)
Alclofenac, a phenylacetic acid derivative with analgesic, antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment of rheumatic disorders. In the late 1970s its use was associated with a high incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the withdrawal of the drug, in some cases voluntarily, from several countries. In others registration has been refused. The reported mutagenic potential has been questioned by some investigators and the drug remains on the market in at least three countries with highly evolved regulatory authorities.Дозировка
Alclofenac when used at 3 g/d in the treatment of rheumatoid arthritis is as effective as 75 mg/d of indomethacin with fewer adverse effects. In the treatment of osteoarthritis 1500 mg/d is as effective and is better tolerated than 300 mg/d of phenylbutazone. Alclofenac has been withdrawn from the market in the United Kingdom because of skin rash and vasculitis (blood vessel inflammation).Алклофенак запасные части и сырье
Алклофенак поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
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8485655694 | United States | 63711 | 58 | |
+1-708-310-1919 +1-13798911105 |
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China | 14623 | 60 | |
025-66028182 18112977050 |
China | 15820 | 58 | |
+86-400-002-6226 | China | 56077 | 58 |