Diisononyl phthalate

Химические свойства

The empirical formula of diisononyl phthalate (DINP) is C26H42O4. The structural formula of DINP varies because the iso-alcohols used in the manufacture contain several isomers. DINP is a clear, colorless to light yellow liquid. DINP is insoluble in water, but it is soluble in organic solvents.

Использование

Diisononyl Phthalate is a general-purpose plasticizer for polyvinyl chloride.

Методы производства

DINP is manufactured by the reaction of phthalic anhydride with isononanol in the presence of an acid catalyst.

Канцерогенность

As stated, there have been two carcinogenesis studies in F344 rats and one in B6C3F1 mice. An increased incidence of hepatocellular neoplasms (i.e., adenomas and carcinomas) is observed in both rats and mice. An increased incidence of renal cell carcinomas and mononuclear cell leukemia has also been described. These studies establish that at dose levels of approximately 600 mg/kg/day, DINP can induce hepatocellular carcinoma in rats and mice. As there was evidence of peroxisomal proliferation at the carcinogenic doses in both species, it seems most likely that this was the mechanism for hepatocellular carcinoma induction. The renal cell carcinomas observed in the male rats were associated with the induction of α 2u-globulin, indicating that it was a sex- and species-specific effect. Kidney tumors that are the consequence of α 2u-globulin induction are not considered to be clinically relevant to humans.MNCL is a tumor type that occurs spontaneously at a high and variable frequency in F344 rats. Because there is no human equivalent, MNCL is not considered to be relevant to humans.