Пропифеназон

Описание

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Химические свойства

solid

Использование

Analgesic; antipyretic; anti-inflammatory.

Определение

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

Всемирная организация здравоохранения(ВОЗ)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

использованная литература

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)