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Пропофол
- английское имяPropofol
- CAS №2078-54-8
- CBNumberCB4101882
- ФормулаC12H18O
- мольный вес178.27
- EINECS218-206-6
- номер MDLMFCD00008885
- файл Mol2078-54-8.mol
Температура плавления | 18 °C (lit.) |
Температура кипения | 256 °C/764 mmHg (lit.) |
плотность | 0.962 g/mL at 25 °C (lit.) |
давление пара | 5.6 mm Hg ( 100 °C) |
показатель преломления | n |
Fp | >230 °F |
температура хранения | 2-8°C |
растворимость | Very slightly soluble in water, miscible with hexane and with methanol |
пка | pKa 11.10(H2O,t =20)(Approximate) |
форма | <18°C Solid,>18°C Liquid |
цвет | Pale Yellow to Yellow |
Запах | at 100.00?%. mild phenolic |
Растворимость в воде | Very slightly soluble in water. |
Мерк | 14,7834 |
БРН | 1866484 |
ИнЧИКей | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
LogP | 3.790 |
Справочник по базе данных CAS | 2078-54-8(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | YI7VU623SF |
Словарь наркотиков NCI | Diprivan |
Код УВД | N01AX10 |
Справочник по химии NIST | Phenol, 2,6-bis(1-methylethyl)-(2078-54-8) |
Система регистрации веществ EPA | 2,6-Diisopropylphenol (2078-54-8) |
Коды опасности | Xn,T,F | |||||||||
Заявления о рисках | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 | |||||||||
Заявления о безопасности | 26-36/37/39-37/39-36-45-36/37-16-7 | |||||||||
РИДАДР | 2810 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | SL0810000 | |||||||||
TSCA | Yes | |||||||||
Класс опасности | 6.1(b) | |||||||||
Группа упаковки | III | |||||||||
кода HS | 29089990 | |||||||||
Банк данных об опасных веществах | 2078-54-8(Hazardous Substances Data) | |||||||||
Токсичность | dog,LD50,intravenous,30mg/kg (30mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996. | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
H335:Может вызывать раздражение верхних дыхательных путей.
H302:Вредно при проглатывании.
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оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Пропофол химические свойства, назначение, производство
Описание
Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.Химические свойства
Light Yellow LiquidИспользование
Propofol is an anesthetic used in veterinary medicine.Всемирная организация здравоохранения(ВОЗ)
Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.Биологические функции
Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney.Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.
Общее описание
Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.Биологическая активность
Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.Фармаколо?гия
Propofol is primarily a hypnotic drug with substantial cardiorespiratory depressant actions and with no ability to produce neuromuscular blockade. While propofol lacks analgesic properties, its use permits lower doses of opioids. Likewise, less propofol is required for adequate hypnosis when it is administered with opioids.Thus, it is said that propofol and opioids interact synergistically.Клиническое использование
Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.Побочные эффекты
The dose of propofol should be reduced in older patients; however, it does have a relatively linear dose– response characteristic, and patients generally can be safely titrated. The pain on injection, especially when small veins are used, can be considerably reduced if lidocaine 20 mg is administered first.Anesthesia induction with propofol causes a significant reduction in blood pressure that is proportional to the severity of cardiovascular disease or the volume status of the patient, or both. However, even in healthy patients a significant reduction in systolic and mean arterial blood pressure occurs. The reduction in pressure appears to be associated with vasodilation and myocardial depression. Although propofol decreases systemic vascular resistance, reflex tachycardia is not observed. This is in contrast to the actions of thiopental. The heart rate stabilization produced by propofol relative to other agents is likely the result of either resetting or inhibiting the baroreflex, thus reducing the tachycardic response to hypotension.
Since propofol does not depress the hemodynamic response to laryngoscopy and intubation, its use may permit wide swings in blood pressure at the time of induction of anesthesia. Propofol should be used with utmost caution in patients with cardiac disease.
Профиль безопасности
Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOLПропофол запасные части и сырье
Пропофол поставщик
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+8613043004613 | China | 305 | 58 | ||
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+8617756083858 | China | 994 | 58 |
Пропофол Обзор)
- 2,6-диметилфенола
- Диэтил isopropylmalonate
- Лития диизопропиламид
- 1-метил-2-пирролидинон
- Диизопропиламин
- N,N'-диизопропилкарбoдиимид
- 2-изопропилфенол
- N,N-Диизопропилэтиламин
- 4-изопропилфенола
- ДИФЕНИЛОВЫЙ ЭФИР
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