Мидекамицин

Описание

Midecamycin, a macrolide antibiotic having a 16-membered lactone ring, was found in the culture broth of Streptomyces mycarofaciens by Meiji Seika Kaisha in 1971. Under specific culture conditions, it is produced by the organism as a single component. Midecamycin shows almost the same antimicrobial spectrum and activity as kitasamycin. Although its serum and urine concentrations are low, it distributes in tissues at high concentration following oral administration.

Химические свойства

White Solid

Использование

A 16-membered ring macrolide antibiotic used in ophthalmology as well as other medical fields.

Фармацевтические приложения

A naturally occurring metabolite of Streptomyces mycarofaciens, supplied as the native compound and as midecamycin acetate for oral administration.
It is rapidly and extensively metabolized and is said to exhibit less toxicity than earlier macrolides. It is of limited availability.