2-Methyl-4,6-dinitrophenol
- русский язык имя
- английское имя2-Methyl-4,6-dinitrophenol
- CAS №534-52-1
- CBNumberCB5152205
- ФормулаC7H6N2O5
- мольный вес198.13
- EINECS208-601-1
- номер MDLMFCD00007105
- файл Mol534-52-1.mol
химическое свойство
| Температура плавления | 83-85 °C(lit.) |
| Температура кипения | 196°C 1012mm |
| плотность | 1.5928 (rough estimate) |
| давление пара | 5.2(x 10-5 mmHg) at 25 °C (Melnikov, 1971)5(x 10-5 mmHg) at 20 °C (ACGIH, 1986) |
| показатель преломления | 1.5460 (estimate) |
| Fp | 11 °C |
| температура хранения | 0-6°C |
| растворимость | Solubility Sparingly soluble in water; readily soluble in ethanol, acetone, ether |
| пка | 4.42(at 25℃) |
| цвет | Yellow prisms |
| Водородный показатель | Colorless (2.4) to yellow (3.8) |
| Растворимость в воде | slightly soluble |
| Мерк | 3279 |
| БРН | 2054389 |
| констант закона Генри | 1.4(x 10-6 atm?m3/mol) at 25 °C (gas stripping-UV spectrophotometry, Warner et al., 1987) |
| Пределы воздействия | NIOSH REL: TWA 0.2 mg/m3, IDLH 5 mg/m3; OSHA PEL: TWA 0.2 mg/m3. |
| Основное приложение | Explosives, fungicides, herbicides, insecticides, pesticides, antitumor agent |
| Справочник по базе данных CAS | 534-52-1(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 4-5 |
| FDA UNII | 1604ZJR09T |
| Справочник по химии NIST | Phenol, 2-methyl-4,6-dinitro-(534-52-1) |
| Система регистрации веществ EPA | 4,6-Dinitro-o-cresol (534-52-1) |
больше
| Коды опасности | T+,N,T,F | |||||||||
| Заявления о рисках | 26/27/28-38-41-43-44-50/53-68-40-39/23/24/25-23/24/25-11-52/53-51/53 | |||||||||
| Заявления о безопасности | 36/37-45-60-61-16-7 | |||||||||
| РИДАДР | UN 1598 6.1/PG 2 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.2 mg/m3 [skin] | |||||||||
| WGK Германия | 2 | |||||||||
| RTECS | GO9625000 | |||||||||
| Класс опасности | 6.1(a) | |||||||||
| Группа упаковки | II | |||||||||
| Банк данных об опасных веществах | 534-52-1(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 in rats (mg/kg): 25-40 orally, 200-600 dermally (Ben-Dyke) | |||||||||
| ИДЛА | 5 mg/m3 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H315：При попадании на кожу вызывает раздражение.
H318：При попадании в глаза вызывает необратимые последствия.
H317：При контакте с кожей может вызывать аллергическую реакцию.
H341：Предполагается, что данное вещество вызывает генетические дефекты.
H300+H310+H330：Смертельно при проглатывании, при контакте с кожей или при вдыхании.
H410：Чрезвычайно токсично для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P302+P352+P310：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Немедленно обратиться за медицинской помощью.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
2-Methyl-4,6-dinitrophenol химические свойства, назначение, производство
Химические свойства
yellow to yellow-green crystals or cryst. powderИспользование
2-Methyl-4,6-dinitrophenol can be used as dormant ovicidal spray for fruit trees (highly phytotoxic and cannot be used successfully on actively growing plants); herbicide; insecticide.Методы производства
o-Cresol is sulfonated in excess 75 % sulfuric acid to give the disulfonic acid. The sulfonation mass is diluted with water, and 2 equivalents of nitric acid are added at 70 ℃ to form the dinitro derivative. The product is separated while molten and washed with hot water.Определение
ChEBI: A hydroxytoluene that is o-cresol carrying nitro substituents at positions 4 and 6.Общее описание
A yellow solid. Emits toxic oxides of nitrogen fumes when heated to decomposition. Toxic by skin absorption, inhalation or ingestion. Soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides.Реакции воздуха и воды
Slightly soluble in water.Угроза здоровью
Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person.Пожароопасность
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.Сельскохозяйственное использование
Herbicide, Fungicide, Pesticide: DNOC is widely used in agriculture as a herbicide and pesticide; it is also used in the dyestuff industry. Although 4,6-dinitro-o-cresol (DNOC) is no longer registered for use in the United States, it was used as a blossom-thinning agent on fruit trees and as a fungicide, insecticide, and miticides on fruit trees during the dormant season. It is used in mushroom houses to control foreign fungi; to kill locusts and other insects; and as a pre-harvest desiccant of potatoes and leguminous seed crops. DNOC is used as free radical polymerization inhibitor and agricultural chemical intermediate; widely used in agriculture as a herbicide and pesticide; Hence, individuals formulating or spraying the compound incur the highest risk of exposure to the compound. Not approved for use in EU countries. DNOC’s registration in the U.S. as a pesticide was canceled in 1991. Currently, there are 39 global suppliers.Торговое название
ANTINONIN®; ANTINONNIN®; ARBOROL®; DEGRASSAN®; DEKRYSIL®; DETAL®; DILLEX®; DINOC®; DINURANIA®; DITROSOL®; DNOC®[C]; EFFUSAN®; EFFUSAN 3436®; ELGETOL®; ELGETOL 30®; ELIPOL®; EXTRAR®; FLAVIN-SANDOZ®; HEDOLIT®; HEDOLITE®; K III®; K IV®; KREOZAN®; KREZOTOL 50®; LIPAN®; NEUDORFF DN 50®; NITROFAN®; PROKARBOL®; RAFEX®; RAFEX 35®; RAPHATOX®; SANDOLIN®; SANDOLIN A®; SELINON®; SINOX®; WINTERWASH®Профиль безопасности
Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardlac and gastrointestinal changes. Mutation data reported. An e~7e and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and other dinitrocresol entries.Канцерогенность
In one chronic feeding study in rats DNOC did not cause an increased incidence of any type of tumor. DNOC was clastogenic, increasing the frequency of chromosomal aberrations both in vivo and in vitro. Conflicting results for mutagenicity have been obtained in bacterial assays.The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for dinitro-o-cresol is 0.2mg/m3 with a notation for skin absorption.
Экологическая судьба
Soil/Plant. In plants and soils, the nitro groups reduced to amino groups (Hartley and Kidd, 1987). When 4,6-dinitro-o-cresol was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum, no signi?cant biodegradation and necessary acclimation for optimum biooxidation within the 4-week incubation period was observed (Tabak et al., 1981).Chemical/Physical. 4,6-Dichloro-o-cresol will react with amines and alkali metals forming water-soluble salts which are indicative of phenols (Morrison and Boyd, 1971).
Метаболический путь
DNOC is metabolised in soils, plants and animals via common metabolic pathways. The primary reaction is the reduction of the nitro groups to the corresponding amino-analogues. Acetylation and deamination via hydroxylation/elimination follow. N- and O-Conjugation as glucosides and glucuronides occurred in plants and animals. The metabolic pathways of DNOC are presented in Scheme 1.Методы очистки
The cresol crystallises from aqueous EtOH. [Beilstein 6 H 369, 6 III 1276.]2-Methyl-4,6-dinitrophenol запасные части и сырье
2-Methyl-4,6-dinitrophenol поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
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