Мозаваптан
- английское имяMozavaptan
- CAS №137975-06-5
- CBNumberCB51388577
- ФормулаC27H29N3O2
- мольный вес427.54
- EINECS1312995-182-4
- номер MDLMFCD00908918
- файл Mol137975-06-5.mol
химическое свойство
| Температура плавления | 213 - 217°C |
| Температура кипения | 543.0±50.0 °C(Predicted) |
| плотность | 1.21±0.1 g/cm3(Predicted) |
| температура хранения | Sealed in dry,Room Temperature |
| растворимость | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| форма | Solid |
| пка | 13.04±0.70(Predicted) |
| цвет | White to Off-White |
| FDA UNII | 17OJ42922Y |
Мозаваптан химические свойства, назначение, производство
Описание
Mozavaptan is an oral vasopressin V2 antagonist that has been launched in Japan for inappropriate antidiuretic hormone secretion syndrome (IADHS), an affliction manifesting as hyponatremia. It joins another nonpeptidic benzazepine, conivaptan, which corrects sodium and water imbalance by blocking the renal V2 receptor resulting in enhanced diuresis, thereby effectively increasing serum sodium concentration. While conivaptan inhibits both V1 and V2 receptors, mozavaptan is significantly more selective for V2 (IC50 of 14nM vs. 1.2 mM for V1).Использование
Mozavaptan is a vasopressin-receptor antagonist. It is used in the treatment of congestive heart failure and hyponatremia.Мозаваптан поставщик
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