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Сталлимицин
- английское имяStallimycin
- CAS №636-47-5
- CBNumberCB51179775
- ФормулаC22H27N9O4
- мольный вес481.51
- файл Mol636-47-5.mol
химическое свойство
Температура плавления | 154-156° |
Температура кипения | 579.2°C (rough estimate) |
плотность | 1.3298 (rough estimate) |
показатель преломления | 1.6910 (estimate) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | 80O63P88IS |
Сталлимицин химические свойства, назначение, производство
Создатель
Herperal,Farmitalia,Italy,1978Производственный процесс
A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.
Терапевтическая функция
AntibioticСталлимицин запасные части и сырье
сырьё
Сталлимицин поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
---|---|---|---|---|
1-631-485-4226; 16314854226 |
United States | 14059 | 65 | |
0755-0755-66853366 13670046396 |
China | 18018 | 56 | |
0571-89903882 13626641628 |
China | 3656 | 58 | |
0571-0571-89903882 15990081639 |
China | 3705 | 58 | |
15868607770 | China | 1163 | 58 | |
4001-009266 17349750668 |
China | 2811 | 58 |