МЕТИЛРТУТИ(II) ХЛОРИД

Химические свойства

white crystals or powder

Использование

Methylmercury(II) chloride is used as a precursor for the preparation of methyl mercury acetate. It is used as a specific reagent (electron stain) for sulfhydryl groups in biological materials like protein as well as demonstration in electron microscopy.

Общее описание

White microcrystals or crystals.

Реакции воздуха и воды

Aqueous solutions at a concentration of 0.25 mg / mL are stable for 3 weeks in the dark at room temperature. Aqueous 0.0001 M solutions show no degradation after 17.1 hours of midday sunlight. High intensity UV irradiation of solutions causes decomposition .

Профиль реактивности

METHYLMERCURY(II) CHLORIDE may be sensitive to light.

Пожароопасность

Flash point data for METHYLMERCURY(II) CHLORIDE are not available; however, METHYLMERCURY(II) CHLORIDE is probably nonflammable.

Профиль безопасности

Poison by ingestion, intramuscular, intravenous, and intraperitoneal routes. Questionable carcinogen with experimental carcinogenic and teratogenic data. Human mutation data reported. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland Hg. See also MERCURY COMPOUNDS.

Канцерогенность

A number of authors have reported carcinogenic effects in rats and mice exposed orally to methylmercury. An association between methylmercury exposure and renal adenocarcinoma was shown in male mice, but no increase in tumor incidence was detected in rats. These findings are supported by reports on methylmercury-induced degeneration of DNA, and inhibition of the formation of the mitotic spindle.
Intoxications with alkoxialkyl or aryl compounds are similar to intoxications with inorganic mercury compounds, as these organomercurials are relativelyunstable. Alkylmercury compounds, such as methylmercury, result in a different syndrome due to the stability of the mercury–methyl binding. The earliest symptoms in adults are paresthesias in the extremities and the face, particularly around the mouth. Later on, disturbances occur inthe motor functions, resulting in ataxia and dysphasia. The visual field is decreased, and, in severe cases, may result in total blindness. These symptoms were observed in large-scale poisonings caused by methylmercury.

Методы очистки

Recrystallise it from absolute EtOH (20mL/g). at 206nm ( 1.37). [See EtHgCl above; Breitinger et al. J Organomet Chem 256 217 1983,max Slotta et al. J Prakt Chem 120 249 1929, Waugh et al. J Phys Chem 59 395 1955, Beilstein 16 IV 1729.]