Epothilone D
- русский язык имя
- английское имяEpothilone D
- CAS №189453-10-9
- CBNumberCB41214330
- ФормулаC27H41NO5S
- мольный вес491.68
- номер MDLMFCD27976357
- файл Mol189453-10-9.mol
химическое свойство
| Температура плавления | 63-66°C |
| альфа | D22 -61.3° (c = 2.5 in methanol) |
| Температура кипения | 663.7±55.0 °C(Predicted) |
| плотность | 1.084±0.06 g/cm3(Predicted) |
| температура хранения | -20°C Freezer |
| растворимость | Soluble in DMSO |
| форма | solid |
| пка | 13.47±0.70(Predicted) |
| цвет | white to off-white |
| ИнЧИКей | XOZIUKBZLSUILX-GIQCAXHBSA-N |
| SMILES | O1[C@H](/C(/C)=C/C2=CSC(C)=N2)CC=C(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC1=O |t:13| |
| Словарь онкологических терминов NCI | epothilone D; KOS-862 |
| FDA UNII | T0358E0YUF |
| Словарь наркотиков NCI | epothilone D |
Epothilone D химические свойства, назначение, производство
Описание
Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions. They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models. Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice. Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice. Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss. Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.Химические свойства
White FoamОпределение
ChEBI: An epithilone that is epithilone C in which the hydrogen at position 13 of the oxacyclohexadec-13-ene-2,6-dione macrocycle has been replaced by a methyl group.Epothilone D запасные части и сырье
запасной предмет
Epothilone D поставщик
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